Growth Restriction and Genomic Imprinting-Overlapping Phenotypes Support the Concept of an Imprinting Network

Intrauterine and postnatal growth disturbances are major clinical features of imprinting disorders, a molecularly defined group congenital syndromes caused by molecular alterations affecting parentally imprinted genes. These genes expressed monoallelically in parent-of-origin manner, they have an impact on human development. In fact, several with exclusive expression from the paternal allele been shown to promote foetal growth, whereas maternally suppress it. The evolution this correlation might be explained different interests maternal genomes, aiming for conservation resources multiple offspring versus extracting maximal resources. Since not all higher mammals show same pattern species, findings animal models always transferable human. Therefore, disorders serve as understand complex regulation interaction loci. This knowledge is prerequisite development precise diagnostic tools therapeutic strategies patients affected disorders. review we will specifically overview current associated retardation, its increasing relevance personalised medicine direction need multidisciplinary approach.